(1 alpha, 2 beta, 3 beta, 4 alpha)-1,2-bis[N-propyl-N-(4-phenoxybenzyl) amino]carbonyl]cyclobutane-3,4-dicarboxylic acid (A-87049): a novel potent squalene synthase inhibitor

J Med Chem. 1997 Jul 4;40(14):2123-5. doi: 10.1021/jm970058x.
No abstract available

MeSH terms

  • Amides / chemical synthesis*
  • Amides / chemistry
  • Amides / pharmacology
  • Animals
  • Anticholesteremic Agents / chemical synthesis*
  • Anticholesteremic Agents / chemistry
  • Anticholesteremic Agents / pharmacology
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Dicarboxylic Acids / chemical synthesis*
  • Dicarboxylic Acids / chemistry
  • Dicarboxylic Acids / pharmacology
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Farnesyl-Diphosphate Farnesyltransferase / antagonists & inhibitors*
  • Female
  • Indicators and Reagents
  • Lovastatin / pharmacology
  • Macaca fascicularis
  • Male
  • Molecular Structure
  • Structure-Activity Relationship

Substances

  • A 87049
  • Amides
  • Anticholesteremic Agents
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Dicarboxylic Acids
  • Enzyme Inhibitors
  • Indicators and Reagents
  • Cholesterol
  • Lovastatin
  • Farnesyl-Diphosphate Farnesyltransferase